A a 5-wk dietary treatment of GFE (200 mg/kg diet) significantly reduced the protein expression of EGFR, p-EGFR, and p-ERK in MDA-MB-468 [breast cancer] tumors by 56%, 54%, and 32.5%, respectively. Overall, dietary GFE inhibited tumor growth, as measured by wet weight, by 32% (P < 0.01).The study authors concluded
These data showed that dietary GFE induced significant growth inhibition of MDA-MB-468 cells in vitro and in vivo through a mechanism involving the EGFR/ERK signaling pathway, suggesting that GFE may have a protective effect for women against EGFR-overexpressing BC [breast cancer]. [emphasis added]Given these findings the time may be ripe for reconsideration of graviola in the prevention and/or treatment of cancers, such as colon and breast cancer. Read more at: GreenMedInfo.com
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